Glue Jobs are basically a serverless version of Spark running on AWS, this means you don't have to size your cluster. The cool part is that you can setup a crawler on top of your RDS database, and using this metadata information to query RDS from a Glue job, and only then load it to Redshift after some transformation. Here the reference: https://aws.amazon.com/blogs/database/how-to-extract-transform-and-load-data-for-analytic-processing-using-aws-glue-part-2/

Using DataPipeline you will always fail the vertical scaling of your EC2 machine. Another solution, if you want to use DataPipeline, is how your process the data, for example, you can make chunked requests to RDS, save the result to S3, only then loading to Redshift. This solution will require much more effort and orchestration skills.