Comparing TypeScript and JavaScript to ExpressJS is like comparing apples to oranges. ExpressJS is a framework for the server-side of web applications in Node.js. You can write programs for ExpressJS and similar frameworks such as NestJS, Feathers, Hapi in either JavaScript or TypesScript. Node.js is really JavaScript for the server side. TypeScript is the typed version of JavaScript. You need some framework for the server side. So ExpressJS is a must. You should focus your attention on selecting the framework. Some frameworks are better with TypeScript such as NestJS. But all can be used with JavaScript. There are advantages to using type declarations but some people, and I included thing it complicates your programming.