1. Synchronous vs. Asynchronous: One of the key differences between RxJS and axios is how they handle asynchronous operations. RxJS is based on the concept of Observables, which allows for reactive programming and provides powerful tools for handling asynchronous workflows. On the other hand, axios is a promise-based library that follows the traditional approach of handling asynchronous operations using promises.

2. Granularity of control: RxJS provides a finer level of control over asynchronous operations compared to axios. With RxJS, developers can easily create complex asynchronous workflows, combining and transforming data streams with powerful operators. This level of control allows for more flexibility and enables the creation of highly customized asynchronous operations. In contrast, axios provides a more straightforward and simplified approach to handling asynchronous requests, without the same level of control over the data stream.

3. Stream-based vs. Single-request: RxJS is built around the concept of data streams and allows for the manipulation and transformation of these streams using operators. It enables developers to handle continuous data updates and create reactive applications. In contrast, axios focuses on making single HTTP requests and does not have built-in support for data streams or continuous updates.

4. Functional vs. Imperative programming: RxJS promotes functional programming paradigms and encourages developers to write code that is more declarative and focused on transforming data streams. It provides a rich set of operators and tools for operating on data streams. On the other hand, axios follows an imperative programming approach, allowing developers to define step-by-step instructions for handling asynchronous requests.

5. Complexity vs. Simplicity: Due to its powerful features and rich set of operators, RxJS can be more complex to work with compared to axios. It requires a steep learning curve for developers to fully grasp the concepts of reactive programming and how to effectively use the different operators. On the other hand, axios is known for its simplicity and ease of use, providing a straightforward way to make HTTP requests without the complexity of reactive programming.

6. Browser vs. Node.js: Another key difference between RxJS and axios is their compatibility. RxJS is designed to work both in the browser and in Node.js environments, making it suitable for universal JavaScript applications. On the other hand, axios is primarily targeted towards browser environments and may require additional configuration or libraries to be used in Node.js.

In Summary, RxJS and axios differ in their approach to handling asynchronous operations, level of control, support for data streams, programming paradigms, complexity, and compatibility with different environments.