At Shopify, over the years, we moved from shards to the concept of "pods". A pod is a fully isolated instance of Shopify with its own datastores like MySQL, Redis, Memcached. A pod can be spawned in any region. This approach has helped us eliminate global outages. As of today, we have more than a hundred pods, and since moving to this architecture we haven't had any major outages that affected all of Shopify. An outage today only affects a single pod or region.
As we grew into hundreds of shards and pods, it became clear that we needed a solution to orchestrate those deployments. Today, we use Docker, Kubernetes, and Google Kubernetes Engine to make it easy to bootstrap resources for new Shopify Pods.