I have been using Node.js lately, and I find it awesome. Although I am using TypeScript (TS), and Deno.js claims to have an easier and better integration with the amazing JS superset, I do not find appealing. The truth is I have not used Deno.js, but I have seen some tutorials when it was first released. However, I would definitely recommend Node.js, especially for a big/serious project, like an e-commerce website / application. The community is huge and you can find answers to your questions or issues, far more easily. Also, I do not know if many packages/libraries are supported by Deno.js yet, so that might be an issue.