It's possible by using the webview plugin.

I wouldn't recommend you to use Vue.js nor React.js as it would be too overblown if what you want to do is a videogame, if that's not the case then use React native for mobiles or NWjs/Electron with whatever frontend framework (maybe give it a try with Vue?) but do not use Unity 3D.

I imagine you know how to do frontend by the questions you asked, so for videogames vanilla CSS is the best. And if you aren't handy with CSS you can always use Bootstrap or Tailwind.