Sri Majji

If this is for learning about how to design the system, then pick the tools are you are confortable with.

Often times, I get stuck picking the tools (and trying to learn about them) vs actually trying to design the system itself.

If you are familiar with React (check out Expo) and Django then I would recommend going with that.

For deploying your backend, I would go with a provider like https://zeit.co/ that automates a whole bunch of deployment steps with their cli tools that you might have to do with AWS.