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I think next step could be to use Koa but I am not sure.
Unlike our frontend, we chose Flask, a microframework, for our backend. We use it with Python 3 and Gunicorn.
One of the reasons was that I have significant experience with this framework. However, it also was a rather straightforward choice given that our backend almost only serves REST APIs, and that most of the work is talking to the database with SQLAlchemy .
We could have gone with something like Hug but it is kind of early. We might revisit that decision for new services later on.
Recently I have been working on an open source stack to help people consolidate their personal health data in a single database so that AI and analytics apps can be run against it to find personalized treatments. We chose to go with a #containerized approach leveraging Docker #containers with a local development environment setup with Docker Compose and nginx for container routing. For the production environment we chose to pull code from GitHub and build/push images using Jenkins and using Kubernetes to deploy to Amazon EC2.
We also implemented a dashboard app to handle user authentication/authorization, as well as a custom SSO server that runs on Heroku which allows experts to easily visit more than one instance without having to login repeatedly. The #Backend was implemented using my favorite #Stack which consists of FeathersJS on top of Node.js and ExpressJS with PostgreSQL as the main database. The #Frontend was implemented using React, Redux.js, Semantic UI React and the FeathersJS client. Though testing was light on this project, we chose to use AVA as well as ESLint to keep the codebase clean and consistent.
I'm building most projects using: Server: either Fastify (all projects going forward) or ExpressJS on Node.js (existing, previously) on the server side, and Client app: either Vuetify (currently) or Quasar Framework (going forward) on Vue.js with vuex on Electron for the UI to deliver both web-based and desktop applications for multiple platforms.
The direct support for Android and iOS in Quasar Framework will make it my go-to client UI platform for any new client-side or web work. On the server, I'll probably use Fastly for all my server work, unless I get into Go more in the future.
Update: The mobile support in Quasar is not a sufficiently compelling reason to move me from Vuetify. I have decided to stick with Vuetify for a UI for Vue, as it is richer in components and enables a really great-looking professional result. For mobile platforms, I will just use Cordova to wrap the Vue+Vuetify app for mobile, and Electron to wrap it for desktop platforms.