1. Layout and Structure: Material Design for Angular provides a more opinionated layout and structure for building web applications, while Skeleton offers a minimal and lightweight grid system without opinionated styles.

2. Component Library: Material Design for Angular comes with a comprehensive set of pre-built components such as buttons, cards, and sliders, while Skeleton focuses mainly on providing a basic framework for developers to create their own components.

3. Theming and Customization: Material Design for Angular comes with a well-defined theming system that allows for easy customization and branding of applications, while Skeleton provides minimal theming options, focusing more on simplicity and speed.

4. Animations and Interactions: Material Design for Angular includes pre-built animations and interactions to enhance user experience, while Skeleton keeps animations minimal and allows developers to add custom interactions as needed.

5. Browser Support: Material Design for Angular is optimized and fully supported on modern browsers, providing a seamless experience for users, while Skeleton may have limited support for older browsers due to its minimalistic approach.

6. Development Community: Material Design for Angular has a larger and more active development community, offering extensive resources, tutorials, and support for developers, whereas Skeleton's community may be smaller and resources less readily available.

In Summary, Material Design for Angular offers a comprehensive component library, theming system, and pre-built animations, while Skeleton focuses on minimalism and simplicity in layout and structure, catering to different needs and preferences in web development.