1. 1. Syntax: Blade and Jinja2 have different syntaxes. Blade uses PHP-like syntax with directives enclosed in @ symbols, while Jinja2 uses a Python-like syntax with directives enclosed in {% ... %} or {{ ... }} symbols.
2. 2. Template Inheritance: Blade supports template inheritance, allowing you to define a base template with common elements and extend it in child templates. Jinja2 also supports template inheritance, but it provides more flexibility with multiple inheritance and template inclusion.
3. 3. Extensions and Filters: Blade does not have a built-in mechanism for extensions or filters. Jinja2, on the other hand, provides a powerful mechanism for extending the template functionality with custom filters, functions, and tests.
4. 4. Escaping: Blade automatically escapes user input by default, preventing cross-site scripting (XSS) attacks. Jinja2 does not automatically escape user input, but provides a convenient |safe filter to mark content as safe and prevent escaping.
5. 5. Control Structures: Blade offers simplified control structures, such as @if, @foreach, and @while, making it easier to write conditional and loop statements in templates. Jinja2 provides similar control structures, but with slightly different syntax and additional features like filters and macros.
6. 6. Integration: Blade is tightly integrated with the Laravel framework and provides features like route/url generation, form opening/closing, and model binding. Jinja2 is a standalone templating engine that can be used with various Python web frameworks like Flask and Django.

In Summary, Blade and Jinja2 differ in syntax, template inheritance, extensions and filters, escaping, control structures, and integration with frameworks.