1. Key Difference 1: Core Functionality - Bootstrap is a CSS framework that provides ready-to-use components and styling options, while React is a JavaScript library for building user interfaces. Bootstrap focuses on providing a responsive design system, grid layout, and prebuilt components like buttons and forms, making it easy to create a visually appealing website. React, on the other hand, focuses on creating reusable UI components, managing component state, and handling the rendering of those components efficiently.

2. Key Difference 2: Dependency - Bootstrap is dependent on jQuery and JavaScript for its interactive components and functionality. It requires both these dependencies to be included in the project. In contrast, React is independent of any external dependencies and does not require jQuery or any other additional libraries. This makes React a lightweight and standalone solution, reducing the overall size and complexity of the project.

3. Key Difference 3: DOM Manipulation - Bootstrap primarily focuses on DOM manipulation and modifying the existing HTML structure using CSS classes and JavaScript. It enhances the interactivity and appearance of the website by adding or removing classes and manipulating the DOM. React, on the other hand, follows a virtual DOM approach, which means it creates a virtual representation of the actual DOM and updates only the necessary parts when the state or props of a component change. This results in better performance and improved efficiency.

4. Key Difference 4: Reusability and Component-Based Architecture - React is built around the concept of reusable components. These components are modular and can be composed together to create complex UI structures. They can also be reused across projects, resulting in improved code maintainability and reusability. Bootstrap provides prebuilt components and styles, but they are not as granular and customizable as React components. React components can be customized and extended to match specific design requirements, and they offer greater flexibility in terms of functionality and styling.

5. Key Difference 5: Development Workflow - Bootstrap follows a traditional web development workflow where the focus is on writing HTML and CSS code. It provides prebuilt classes and styles that can be applied directly to HTML elements. React, on the other hand, introduces a component-centric development workflow. Developers define reusable and modular components using JavaScript and JSX syntax, which ultimately get rendered as HTML and CSS. This workflow encourages a more organized and scalable approach to development, and it enables easier collaboration between frontend and backend developers.

6. Key Difference 6: Learning Curve - Bootstrap is relatively easy to learn, especially for developers with a basic understanding of HTML and CSS. It provides clear documentation and examples that make it straightforward to implement. React, on the other hand, has a steeper learning curve, especially for developers who are new to JavaScript frameworks. It requires a solid understanding of JavaScript, JSX syntax, and component-based architecture. However, once mastered, React offers greater flexibility and scalability in building complex and interactive web applications.

In Summary, Bootstrap is a CSS framework for creating visually appealing websites with prebuilt components and responsive design, while React is a JavaScript library for building reusable UI components and managing state efficiently, following a component-based architecture. Bootstrap relies on jQuery and JavaScript for interactivity, while React is independent of external dependencies. React follows a virtual DOM approach and offers better reusability, customizability, and development workflow, at the cost of a steeper learning curve.