1. File Size and Dependencies: Tailwind CSS generates a larger file size due to its utility-first approach, which includes all possible utility classes in the build, whereas gentelella focuses on more specific styled components, resulting in smaller file sizes with less unnecessary code.
2. Design Philosophy: Tailwind CSS promotes a utility-first approach where styles are applied directly to HTML elements, offering flexibility but potentially leading to more verbose markup, while gentelella follows a component-based approach that enables cleaner, more modular code but with limited flexibility in customization.
3. Customization and Extensibility: Tailwind CSS allows for extensive customization through its configuration file, enabling developers to tailor the framework to their specific needs, while gentelella provides fewer customization options out of the box, requiring more manual editing to modify styles.
4. Learning Curve: Tailwind CSS may have a steeper learning curve for beginners due to its unique utility class system and configuration options, whereas gentelella, with its more traditional component-based structure, might be easier for beginners to grasp initially.
5. Community and Support: Tailwind CSS boasts a large and active community, providing ample resources, tutorials, and pre-built components, while gentelella may have a smaller community, resulting in fewer readily available resources and support channels for developers.
6. Integration with JavaScript Frameworks: Tailwind CSS integrates well with modern JavaScript frameworks like React and Vue.js, offering components and plugins for seamless integration, whereas gentelella may require more manual work and customization to integrate smoothly with these frameworks.

In Summary, Tailwind CSS and gentelella differ in file size and dependencies, design philosophy, customization and extensibility, learning curve, community and support, and integration with JavaScript frameworks.