1. Routing: Beego uses a traditional hierarchical routing system where routes are matched in the order they are defined in the code. On the other hand, Iris utilizes flexible, dynamic routing with support for subdomains, regex routing, and wildcard matching, providing more granular control over routing behavior.

2. Middleware: Beego has a simpler middleware implementation with a global middleware stack that runs for every request. In contrast, Iris offers a more modular and customizable middleware system allowing developers to define middleware for specific routes or groups of routes, providing better flexibility and organization.

3. Performance: Beego is known for its impressive performance and speed, but Iris takes it a step further with its highly optimized design and advanced features such as fasthttp server integration, making it one of the fastest Golang web frameworks available in terms of raw performance.

4. Built-in Tools: Beego comes with a built-in ORM, form validation, and other tools to streamline development, while Iris focuses more on providing a lightweight core with optional modules and extensions for additional functionality, allowing developers to choose and integrate only the components they need.

5. Learning Curve: Beego's architecture and design patterns are easier to grasp for beginners and developers coming from other frameworks, making it a good choice for rapid development projects. Iris, with its more advanced features and flexibility, has a steeper learning curve, requiring a deeper understanding of Golang and web development concepts.

6. Community and Ecosystem: Beego has a larger community and ecosystem with more resources, plugins, and community support available. Iris, being a newer and more specialized framework, has a smaller but growing community focused on high-performance web applications, providing more targeted support and resources for specific use cases.

In Summary, Beego is beginner-friendly with a comprehensive set of built-in tools, while Iris offers advanced performance optimizations and flexibility for more experienced developers seeking high-performance web solutions.