1. Ease of Use: Chalice is a microframework for creating application backends in Python, whereas Zappa is a serverless deployment library for Python web applications. Chalice has a simpler interface and requires less code to set up and deploy a serverless application, making it easier for developers to get started. On the other hand, Zappa provides more flexibility and customization options, allowing developers to fine-tune the deployment process according to their specific requirements.

2. Integration with AWS Services: Chalice is tightly integrated with various AWS services such as Amazon API Gateway, AWS Lambda, and Amazon DynamoDB. It provides easy-to-use decorators to define RESTful APIs and seamlessly handle HTTP requests. Zappa also leverages these AWS services but provides more advanced features like automatic scaling, custom domain mapping, and scheduled events. This makes Zappa a more suitable choice for complex applications that require extensive interactions with AWS services beyond just handling HTTP requests.

3. Deployment Process: Chalice simplifies the deployment process by providing a dedicated CLI command (chalice deploy) to deploy the application to AWS. It automatically creates and configures all the necessary resources based on the application configuration. On the other hand, Zappa requires more manual setup and configuration steps, such as creating an IAM role and configuring the AWS Lambda function. Zappa's deployment process can be more cumbersome for developers not familiar with AWS services.

4. Community Support and Maintenance: Chalice is actively maintained by AWS and has a strong community support. It receives regular updates and improvements, ensuring compatibility with the latest AWS services and features. Zappa, on the other hand, is an open-source library maintained by a community of contributors. While it has a dedicated user base, the frequency of updates and bug fixes may vary depending on the availability of contributors.

5. Pricing: Chalice, being an AWS-supported service, comes with the cost of the AWS resources it uses, such as Amazon API Gateway and AWS Lambda. Zappa, being a deployment library, does not have any additional costs beyond the standard AWS resource usage charges. This makes Zappa a more cost-effective choice for small-scale applications or projects with limited budgets.

6. Python Version Support: Chalice supports Python 3.6 or higher. It takes advantage of the latest language features and improvements available in newer Python versions. Zappa, on the other hand, also supports Python 2.7, allowing developers to use older Python versions if required. This can be beneficial for legacy applications or projects that have dependencies on Python 2.7.

In Summary, Chalice offers a simpler interface and streamlined deployment process, while Zappa provides more flexibility, customization options, and advanced features for complex applications. Chalice has better integration with AWS services, active community support, and is maintained by AWS, whereas Zappa is a cost-effective choice and supports both Python 2.7 and Python 3.