1. Configuration: Create React App provides a pre-configured environment with sensible defaults, making it easier to start a project. On the other hand, Deku allows more fine-grained configuration options, giving developers more control over the setup of their project.
2. Community Support: Create React App has a larger community and ecosystem, leading to more resources, plugins, and support available for developers. Deku, being a smaller and less popular framework, may have a smaller community and fewer resources available.
3. State Management: Create React App relies heavily on external state management libraries like Redux for managing application state. Deku, on the other hand, comes with built-in state management using the Deku Context API, reducing the need for external dependencies.
4. Component API: Deku uses a more minimalistic and lightweight component API compared to Create React App, which may appeal to developers looking for a simpler syntax and less boilerplate code.
5. Performance Optimization: Create React App comes with built-in optimizations like code splitting and lazy loading, improving performance by reducing bundle sizes. Deku may require manual optimizations for performance improvements, as it does not offer these features out of the box.

In Summary, Create React App provides a pre-configured environment with a larger community and external state management options, while Deku offers more configuration control, built-in state management, a minimalistic component API, and may require manual performance optimizations.