1. Component-based vs. Model-View-Controller (MVC) architecture: Material Design for Angular emphasizes a component-based architecture, where components encapsulate all the necessary functionality and display elements. On the other hand, PHP-MVC follows the MVC design pattern, separating the application into models, views, and controllers.

2. Design Language and Components: Material Design for Angular provides a specific design language and a collection of pre-built components that adhere to that design language, ensuring a consistent look and feel across applications. PHP-MVC, on the other hand, does not enforce a specific design language or provide pre-built UI components.

3. Server-side vs. Client-side rendering: PHP-MVC primarily renders content on the server-side before sending it to the client, while Material Design for Angular leverages client-side rendering for a more interactive and responsive user experience.

4. Tooling and Libraries: Material Design for Angular comes with a set of tools and libraries specifically tailored for building Angular applications following the material design guidelines. In contrast, PHP-MVC developers have more flexibility in choosing their tools and libraries, as PHP is a more general-purpose programming language.

5. Community and Support: Material Design for Angular benefits from the large Angular community and support from Google, ensuring regular updates, bug fixes, and documentation. PHP-MVC frameworks may have a smaller community and may vary in terms of support and updates.

6. Testing and Debugging: Material Design for Angular promotes testing and debugging practices through tools like Angular CLI and Angular Testing Library, which might differ from the approach taken in PHP-MVC frameworks for testing and debugging web applications.

In summary, Material Design for Angular focuses on a component-based architecture with a specific design language, while PHP-MVC follows the MVC pattern with more flexibility in design and tooling choices.