1. Syntax: One key difference between MATLAB and VBScript lies in their syntax. MATLAB uses a linear algebra-based syntax, making it more suitable for handling numerical computations and data visualization. On the other hand, VBScript follows a more traditional scripting language syntax, which can be used for automating tasks and working with Windows-based applications.

2. Integration: Another difference is in the integration capabilities of the two languages. MATLAB is specifically designed for scientific and engineering applications, with built-in functions and toolboxes for various disciplines. In contrast, VBScript is better suited for general automation tasks within the Windows operating system, such as scripting actions in software applications or controlling system settings.

3. Variable Declaration: MATLAB does not require explicit variable declaration, as it uses dynamic typing to determine variable types at runtime. VBScript, on the other hand, requires explicit declaration of variables before they can be used, following a more traditional programming approach. This difference can lead to various implications in terms of code structure and flexibility.

4. Error Handling: MATLAB provides built-in error handling mechanisms, such as try-catch blocks, to handle exceptions and errors in code execution. VBScript also supports error handling through techniques like On Error Resume Next and On Error GoTo, but it may require more manual intervention compared to MATLAB's built-in functionalities.

5. Application Scope: MATLAB is typically used in scientific, engineering, and research environments for numerical analysis, data processing, and modeling, while VBScript is commonly employed in automation of Windows-based tasks, user interface interactions, and system administration scripts. This difference in application scope influences the type of problems each language is suited to solve.

6. Development Environment: MATLAB offers a comprehensive integrated development environment (IDE) with debugging tools, visualization capabilities, and an extensive help system. In contrast, VBScript development often relies on external text editors or the Windows Script Host environment, which may result in a less cohesive development experience for programmers.

In Summary, MATLAB and VBScript differ in syntax, integration, variable declaration, error handling, application scope, and development environment, suited for distinct purposes in scientific computation and automation tasks in Windows environments.