React VR

I am about to create a React application that should show a 3-dimensional space where you can click and move.

The goal is to make it accessible in the long run for VR. Important here is that it needs to be compatible with as many browsers as possible.

I am wondering which would be a reasonable way to build this? A-Frame seems very popular but does not seem to be a good choice together with React. So the question is whether to go with plain three.js or to use one of the three.js-based Frameworks, e.g., React VR or react-three-fibre?

I am new to VR. I am in the middle of an investigation and would appreciate the expertise of people who already gained experience in this field. I am happy to answer questions in detail if they are any. Thank you in advance.