1. Default Styling: One key difference between Bootstrap Styled and Chakra UI is their default styling. Bootstrap Styled provides a comprehensive set of pre-defined styles and classes that can be easily applied to elements, giving a consistent and familiar look and feel to websites. On the other hand, Chakra UI takes a more minimalistic approach with its default styling, allowing developers to have more control over the design and appearance of their websites.

2. Theme Customization: Another difference between Bootstrap Styled and Chakra UI is the level of theme customization they offer. Bootstrap Styled provides a variety of pre-built themes that can be easily applied to websites. These themes can be customized by modifying the default variables and CSS classes. Chakra UI, on the other hand, allows developers to fully customize the theme by modifying the global style object. This gives developers more flexibility and control over the overall design of their websites.

3. Component Library: Bootstrap Styled and Chakra UI also differ in terms of their component library. Bootstrap Styled offers a wide range of reusable components such as buttons, forms, modals, and navigation bars, making it easy to build complex layouts and interactive UI elements. Chakra UI, on the other hand, takes a more minimalist approach with its component library. It provides a smaller set of essential components that are designed to be highly customizable and accessible.

4. Accessibility: When it comes to accessibility, both Bootstrap Styled and Chakra UI have a strong focus on ensuring that websites built with their frameworks are accessible to all users. However, Chakra UI has a stronger emphasis on accessibility, providing built-in support for keyboard navigation, screen readers, and other accessibility features. It also follows the best practices and guidelines outlined in the WAI-ARIA specification, making it easier for developers to create accessible websites.

5. Responsive Design: Bootstrap Styled and Chakra UI have different approaches to responsive design. Bootstrap Styled offers a responsive grid system that allows developers to create responsive layouts by using a combination of rows and columns. It also provides utility classes for hiding and showing elements at different screen sizes. Chakra UI, on the other hand, uses a responsive design system based on its Box component. This component automatically adjusts its size and layout based on the screen size, making it easier to create responsive designs without the need for complex CSS rules.

6. Integration with React: Both Bootstrap Styled and Chakra UI are popular choices for building responsive and accessible UIs in React applications. However, Chakra UI is specifically designed for React and offers seamless integration with React's component model. It provides a set of custom hooks and context providers that make it easy to use Chakra UI components and styles in React components. Bootstrap Styled, on the other hand, can be used with React, but it doesn't have the same level of integration and ease of use as Chakra UI.

In Summary, Bootstrap Styled and Chakra UI differ in their default styling, theme customization options, component library, emphasis on accessibility, approach to responsive design, and integration with React.