1. Template Engine: Django REST framework is designed for creating web APIs and does not include a template engine like Jinja2 which is specifically built for generating dynamic HTML content.
2. Serialization: Django REST framework provides powerful serialization and deserialization tools for converting complex data types, such as querysets and model instances, into native Python data types that can be easily rendered into JSON or XML.
3. Authentication and Authorization: Django REST framework offers built-in support for authentication and authorization mechanisms, allowing developers to secure their APIs with ease while Jinja2 mainly focuses on rendering templates and does not provide these features out of the box.
4. URL Routing: Django REST framework provides a robust URL routing system that allows developers to define URL patterns for their APIs in a concise and flexible manner, while Jinja2 is primarily focused on rendering templates and does not offer such advanced routing capabilities.
5. Response Handling: Django REST framework simplifies the process of handling API responses by providing powerful response classes and renderers, allowing developers to easily return data in multiple formats such as JSON, XML, or HTML. Jinja2, on the other hand, is more focused on template rendering and does not offer as much flexibility in handling different types of responses.

In Summary, Django REST framework and Jinja2 differ in terms of their purpose, features, and capabilities, where Django REST framework primarily focuses on creating web APIs with advanced serialization, authentication, and URL routing functionalities, while Jinja2 is a template engine designed for generating dynamic HTML content.