1. Syntax and Structure: In PHP-MVC, the syntax can sometimes be less readable due to the mix of PHP and HTML within the code structure. On the other hand, Python provides a more clean and structured syntax making it easier to read and maintain code.
2. Frameworks: PHP-MVC has multiple frameworks like Laravel, CodeIgniter, and Symfony, which can sometimes make it overwhelming to choose the right one for the project. Python, however, has Django and Flask as popular frameworks with clear guidelines and conventions.
3. Community Support: The PHP community is vast and has been around for a longer time, resulting in a wealth of resources and support. Python's community is also strong and growing rapidly, but due to the immense popularity of PHP, it has more extensive community support.
4. Performance: Python tends to be slower than PHP in web development tasks due to its interpreted nature, while PHP's performance is optimized for web development tasks, making it faster in certain scenarios.
5. Type System: PHP is loosely typed, allowing for more flexibility in variable handling but can lead to more errors at runtime. In contrast, Python is strongly typed, ensuring more predictable behavior and catching errors at compile time.
6. Philosophy: PHP-MVC follows an object-oriented approach with a focus on separation of concerns through the Model-View-Controller architecture, while Python emphasizes simplicity, readability, and having one clear way to do things through the "Zen of Python."

In Summary, PHP-MVC emphasizes object-oriented architecture and performance optimization, while Python focuses on clean syntax, community support, and simplicity in development.