1. Flexibility: Pure CSS offers a more flexible approach as it provides a set of CSS modules that can be included individually based on the developer's requirements. On the other hand, Tailwind CSS follows a utility-first approach, where the framework provides a comprehensive set of utility classes that can be used to create complex layouts quickly. This makes Tailwind CSS less flexible but more efficient in terms of development speed.

2. Customizability: Pure CSS allows developers to customize and override any CSS rules provided by the framework to match their design requirements. It provides a set of variables and mixins that can be used to customize the styles. In contrast, Tailwind CSS does not allow direct customization of the provided utility classes. Instead, it encourages developers to extend or configure the framework to create custom utility classes.

3. File Size: Pure CSS has a smaller file size compared to Tailwind CSS as it only includes the CSS modules that are required for a specific project. This results in faster loading times for webpages that use Pure CSS. On the other hand, Tailwind CSS comes with a larger file size due to the inclusion of all utility classes, resulting in slightly slower loading times.

4. Learning Curve: Pure CSS has a relatively steeper learning curve as developers need to familiarize themselves with the various CSS modules and understand how they work together. Tailwind CSS, on the other hand, has a lower learning curve as it follows a simple utility-based approach where developers can apply classes directly in the HTML markup.

5. Design Consistency: Pure CSS provides a consistent design language throughout the project as developers use the same set of CSS modules. This ensures a unified visual style across the entire website. In contrast, Tailwind CSS allows more flexibility in terms of design choices as developers can combine utility classes in various ways. This may result in a less consistent design compared to Pure CSS.

6. Community Support: Pure CSS has been around for a longer time and has a larger community of developers. This means that there are more resources and tutorials available for beginners to learn from. Tailwind CSS, although gaining popularity rapidly, has a smaller community compared to Pure CSS.

In Summary, Pure CSS offers more flexibility, customization options, and a smaller file size compared to Tailwind CSS, while Tailwind CSS provides faster development speed, a simpler learning curve, and more design choices at the cost of some design consistency and community support.