1. User Base: Adobe InDesign is primarily used for desktop publishing, such as creating posters, flyers, and magazines, while Blender is widely known for 3D modeling and animation.

2. Interface: InDesign provides a user-friendly interface tailored for print publication design, with tools like master pages and grid systems, whereas Blender's interface is more complex due to its extensive capabilities in 3D rendering and animation.

3. 3D Capabilities: While both software can handle certain 3D elements, Blender is highly specialized for creating intricate 3D models, animations, and visual effects that surpass the capabilities of InDesign.

4. Pricing Model: Adobe InDesign is subscription-based, with monthly or annual fees, whereas Blender is open-source and available for free to users, making it more accessible to a wider audience.

5. Export Options: InDesign is optimized for exporting to print formats such as PDF or EPS, ensuring high-quality print outputs, while Blender offers diverse export options for various 3D file formats and interactive applications like games.

6. Learning Curve: InDesign has a lower learning curve due to its focus on desktop publishing, making it easier for beginners to pick up, whereas Blender's complex 3D tools require more time and dedication to master.

In Summary, Adobe InDesign specializes in desktop publishing with a user-friendly interface, while Blender excels in 3D modeling and animation with a more complex interface and diverse export options.