1. Efficiency: FilePond uses the QueueUp strategy, where it uploads files one by one in a sequential manner. On the other hand, tus.io uses parallel chunk uploads, allowing multiple chunks of a file to be uploaded simultaneously. This makes tus.io faster and more efficient for larger files.

2. Flexibility: FilePond provides a ready-to-use UI with built-in features for file manipulation, such as cropping and rotating. It also supports various file types and integrates smoothly with popular frontend frameworks. In contrast, tus.io focuses solely on the file upload functionality and does not provide any built-in UI or file manipulation features. This allows for more flexibility, as it can be integrated into any frontend setup.

3. Error Handling: FilePond has extensive error handling mechanisms, providing detailed error messages and options for retrying failed uploads. It also has built-in support for automatic retries and resumable uploads. On the other hand, tus.io provides a simpler error handling mechanism and does not have built-in support for automatic retries or resumable uploads.

4. Backend Support: FilePond supports various server-side technologies, including PHP, Node.js, and ASP.NET. It also has plugins for popular CMS platforms like WordPress and Joomla. On the other hand, tus.io is language-agnostic and can be implemented with any backend technology that supports the tus protocol.

5. Scalability: FilePond is suitable for smaller applications or websites with moderate file upload requirements. It may not be the best option for high-traffic websites or applications that deal with large numbers of concurrent file uploads. tus.io, on the other hand, is designed to handle large-scale file uploads with ease and is better suited for situations that require high scalability.

6. Community and Support: FilePond has a larger and more active community, with extensive documentation, tutorials, and a dedicated support team. It also has a paid version with additional features and priority support. tus.io has a smaller community but still provides documentation and basic support through its website.

In summary, FilePond is a powerful tool with a user-friendly UI and extensive features, suitable for smaller applications. tus.io, on the other hand, is designed for scalability and performance, with a focus on efficient file uploads and compatibility with any backend technology.