1. User Interface: Adobe InDesign is primarily used for layout design and typesetting, making it more suitable for creating multi-page documents such as magazines, books, and brochures. Photoshop, on the other hand, is focused on image editing and manipulation, providing a wide range of tools for retouching photos and creating digital artwork.

2. Vector vs. Raster Graphics: In InDesign, vector graphics are used for creating illustrations, logos, and text that can be scaled without losing quality. In contrast, Photoshop works with raster graphics, which are made up of pixels and are better suited for photo editing and realistic digital artwork.

3. Text Handling: In Adobe InDesign, text handling capabilities are more advanced, offering features like paragraph styles, text wrap, and advanced typographic options, making it the preferred choice for designing large text-heavy documents. Photoshop also has text tools but is more limited compared to InDesign, making it less efficient for text-heavy projects.

4. Output: InDesign is better suited for preparing files for print or digital publishing, with features like preflight checks, PDF export options, and the ability to generate high-quality print-ready files. While Photoshop can generate print files, it mainly focuses on creating web graphics, social media visuals, and digital artwork for online use.

5. Collaboration: InDesign allows multiple users to work on a project simultaneously, with features like InCopy integration for text editing and shared libraries for easy collaboration. Photoshop, on the other hand, is more of a standalone tool, limiting collaboration options for teams working on the same project.

6. Workflow: When it comes to workflow, InDesign is designed for creating and managing multi-page documents with a structured layout, making it ideal for long-form content. Photoshop, on the other hand, is best suited for individual image editing tasks, making it more suitable for creating and enhancing standalone visual assets.

In Summary, Adobe InDesign is preferred for creating multi-page layouts and text-heavy documents with advanced typographic features, while Adobe Photoshop excels in image editing, digital artwork creation, and web graphics design.