1. Rendering Capabilities: Prism is primarily a CSS-based component library that focuses on UI elements and animations using CSS properties, while three.js is a JavaScript library dedicated to creating 3D graphics and animations utilizing WebGL, allowing for more advanced and immersive visual experiences.
2. Complexity: While Prism is simpler and easier to use for basic UI animations and effects, three.js offers more complex features and functionalities, making it suitable for creating intricate 3D scenes and effects that require a higher level of programming knowledge and expertise.
3. Community Support: three.js has a larger and more active community compared to Prism, resulting in more resources, tutorials, and support available for users seeking help or looking to expand their knowledge and skills in creating 3D graphics and animations.
4. Performance: Due to its focus on 3D graphics and animations, three.js is optimized for performance and can handle complex computations and rendering tasks efficiently, making it suitable for high-demanding applications such as real-time simulations or virtual reality experiences.
5. Compatibility: Prism is more limited in terms of compatibility with older browsers and devices due to its reliance on CSS3 properties and animations, while three.js utilizes WebGL for rendering, which provides broader compatibility across different platforms and devices, including mobile devices and VR headsets.

In Summary, Prism and three.js differ in their rendering capabilities, complexity, community support, performance, and compatibility, catering to different needs and levels of expertise in UI/animation design and 3D graphics/animation development.