1. Flexibility of Structure: One key difference between Sanity and prismic.io is the flexibility of structure. In Sanity, the data structure is very flexible, allowing for the creation of custom schemas and relations between different content types. This makes it suitable for complex projects or websites with changing requirements. On the other hand, prismic.io follows a more rigid content model approach where the structure is predefined and it might not be as adaptable to changing requirements or complex relationships between content types.

2. Collaborative Editing: Another difference between Sanity and prismic.io is in their approach to collaborative editing. Sanity offers real-time collaborative editing, allowing multiple users to work on the same content simultaneously and see instant updates. This can be beneficial for teams working on content creation or editing together. However, prismic.io does not provide real-time collaboration out of the box. Users need to manually save and publish changes, which can be limiting for teams that require simultaneous editing.

3. Hosting and Infrastructure: When it comes to hosting and infrastructure, Sanity and prismic.io have different approaches. Sanity is a headless CMS that allows users to host their data wherever they choose, giving them full control over their hosting solution. This can be advantageous for users who require specific hosting configurations or have existing infrastructure in place. In comparison, prismic.io provides an all-in-one hosting solution, taking care of the infrastructure and hosting the content on their own servers. This convenience of hosted infrastructure might be beneficial for users who prefer a simpler setup.

4. Querying and Retrieval of Content: The way content is queried and retrieved differs in Sanity and prismic.io. Sanity uses a powerful query language called GROQ (Graph-Relational Object Queries) which allows for complex queries, filtering, and sorting of content. This can be useful in scenarios where highly customized content queries are required. In contrast, prismic.io uses a more simplified querying system, but it provides features like pagination and filtering that can still meet the needs of most projects.

5. Webhooks and Automation: Sanity and prismic.io handle webhooks and automation differently. In Sanity, webhooks can be set up to trigger automated processes whenever certain events occur, such as content updates or publishing. This allows for easy integration with external services or custom workflows. On the other hand, prismic.io does not natively support webhooks, although it offers a RESTful API that can be used to build custom integrations or automation.

6. Pricing Model: One important difference to consider is the pricing model offered by Sanity and prismic.io. Sanity provides a generous free tier with certain limitations, and their pricing is based on usage, such as the number of API calls, bandwidth, and storage. This can be beneficial for smaller or low-traffic websites. In contrast, prismic.io offers a more traditional tiered pricing model that includes a limited free plan and paid plans with different features and usage limits. The choice of pricing model could depend on the specific needs and budget of a project.

In summary, Sanity offers more flexible structure and collaborative editing abilities, allows users to host their data independently, provides a powerful query language, supports webhooks for automation, and offers a usage-based pricing model. On the other hand, prismic.io follows a more rigid content model approach, provides an all-in-one hosted solution, has a simpler querying system, lacks native webhook support, and has a tiered pricing model.