1. Pricing Model: Statamic has a one-time licensing fee, where users pay for the software and can use it indefinitely without any additional charges. On the other hand, Typo3 is an open-source platform and its core CMS software is available for free. However, users may incur costs for hosting, extensions, and customization.

2. User Interface: Statamic has a user-friendly and intuitive control panel that focuses on simplicity and ease of use. It provides a smooth and streamlined experience for content editors and website administrators. In contrast, Typo3 has a more complex user interface with a steeper learning curve. It offers advanced features and customization options, but requires more technical expertise.

3. Scalability: Typo3 is well known for its scalability and ability to handle large and complex websites with thousands of pages and extensive functionality. It is often the preferred choice for enterprises and large organizations. While Statamic can handle smaller to medium-sized websites effectively, it may face limitations when dealing with extensive content and high traffic volumes.

4. Template System: Statamic uses a simple and flexible template system that is based on the Laravel framework. It provides users with the ability to create and customize templates using a combination of HTML, CSS, and YAML syntax. On the other hand, Typo3 uses TypoScript, a dedicated scripting language, for template creation and configuration. This offers more advanced options for template customization and control.

5. Community and Support: Typo3 has a large and active community of developers and users, providing extensive online resources, documentation, and support forums. It is also backed by TYPO3 GmbH, an organization that offers commercial support services. Statamic, although it has a growing community, may have more limited online resources and support options in comparison.

6. Target Audience: Typo3 caters more towards enterprises, large organizations, and websites with complex requirements. It offers extensive features for multi-language, multi-site, and multi-channel management. On the other hand, Statamic is aimed at smaller to medium-sized websites, agencies, and individual developers who prioritize simplicity, flexibility, and ease of use.

In Summary, Statamic and Typo3 differ in their pricing models, user interfaces, scalability, template systems, community support, and target audience focus. The choice between the two CMS platforms largely depends on the specific needs and requirements of the website project at hand.