1. Project Structure: Vue CLI provides a predefined project structure with templates, plugins, and integrated tools, making it easier for developers to start building Vue.js applications, while anime.js focuses on animation capabilities, allowing for more creative freedom and control over animations.
2. Build Process: Vue CLI simplifies the build process with integrated webpack configurations, hot-reload, and optimized production builds, whereas in anime.js, the focus is on creating complex animations without the need for a build process.
3. Componentization: Vue CLI promotes component-based architecture, enabling developers to create reusable and modular components, which can enhance code maintainability and scalability, whereas anime.js does not enforce a component-based structure as it primarily focuses on animation effects.
4. Template Syntax: Vue CLI leverages Vue's template syntax for data binding and event handling, providing a declarative approach to building interactive interfaces, whereas anime.js uses a JavaScript-based API for creating animations, offering more flexibility and control over the animation process.
5. Community Support: Vue CLI benefits from a large and active community of Vue.js developers, offering extensive documentation, tutorials, and plugins, while anime.js, although popular, may have a smaller community focused specifically on animation-related discussions and support.
6. Learning Curve: Vue CLI may have a steeper learning curve for beginners due to its comprehensive features and configurations, whereas anime.js is relatively easier to grasp, especially for those familiar with JavaScript and animation concepts.

In Summary, Vue CLI focuses on providing a structured environment for building Vue.js applications with enhanced development features, while anime.js specializes in creating advanced and customized animations with a more flexible and JavaScript-centric approach.