React might be a good option if you're considering a mobile app for the future, because of react native. Although, Vue.js has the easiest learning curve and offers a better developer ramp-up time. Vue.js is great to build SPAs, very clean and organized and you won't have a lot of long-term maintenance problems (like AngularJS, for example). Bootstrap can still be used, but with flexbox there's no need anymore.
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