1. Authentication Method: Azure Multi-Factor Authentication uses multiple methods such as phone calls, SMS messages, smart cards, or biometrics for secure authentication, while Django REST framework JWT relies on JSON Web Tokens for authenticating users.
2. Integration with Platforms: Azure Multi-Factor Authentication is specifically designed for integrating with Microsoft Azure services and applications, while Django REST framework JWT is a versatile tool that can be integrated with any Django-based web application.
3. Hosting and Deployment: Azure Multi-Factor Authentication is typically hosted and managed within the Azure cloud environment, whereas Django REST framework JWT can be hosted on any server that supports Python and Django.
4. Cost Structure: Azure Multi-Factor Authentication often involves subscription-based pricing models depending on usage and features, while Django REST framework JWT is open source and free to use, making it more cost-effective for smaller projects.
5. Customization and Extensibility: Azure Multi-Factor Authentication offers limited customization options compared to Django REST framework JWT, which allows developers to customize and extend functionality based on specific project requirements.
6. Scalability: Azure Multi-Factor Authentication may have limitations in terms of scalability depending on the pricing plan chosen, while Django REST framework JWT can be scaled horizontally to handle increased traffic and user loads effectively.

In Summary, Azure Multi-Factor Authentication and Django REST framework JWT differ in their authentication methods, platform integration, hosting options, cost structures, customization abilities, and scalability.