1. Hosting Requirements: Django CMS is built on top of the Django web framework and requires a PostgreSQL database, whereas Statamic is a flat-file CMS that does not require a database, making it easier to host on platforms that do not support databases.
2. Content Structure: Django CMS offers a more traditional content hierarchical structure with the ability to nest pages, while Statamic uses a flat structure where pages are more independent and not nested within each other. This difference in content structure can affect how content is organized and accessed within the CMS.
3. Customization Options: Django CMS provides a robust set of customization options through plugins and extensions, allowing developers to tailor the CMS to specific needs. In comparison, Statamic offers flexibility through its modular approach where components can be easily added or removed to customize the CMS to match project requirements.
4. Template Language: Django CMS uses Django's template language, which can be more familiar to developers already using Django, while Statamic uses its own template language called Antlers, which has a syntax that is specifically designed for Statamic's flat-file approach. Developers may find one template language more suitable based on their existing skill set and familiarity.
5. Open Source vs. Paid Model: Django CMS is an open-source project with a large community contributing to its development, making it freely available for anyone to use and modify. Statamic, on the other hand, follows a paid model with licensing fees for commercial use, which may impact the choice of CMS based on budget constraints or preference for open-source solutions.

In Summary, Django CMS and Statamic differ in hosting requirements, content structure, customization options, template language, and their open-source vs. paid model, offering unique features and functionalities for users to consider when choosing a CMS for their projects.