1. Transaction Speed: Ripple transactions are much faster compared to Skrill as Ripple provides near-instant settlement, typically taking only a few seconds to complete a transaction. On the other hand, Skrill transactions may take longer, often requiring several minutes to process.

2. Transaction Fees: Ripple tends to have lower transaction fees compared to Skrill. Ripple's fees are typically minimal, making it a cost-effective option for international transfers. Skrill, on the other hand, may have higher fees, especially for certain types of transactions or currencies.

3. Currency Support: Ripple primarily focuses on its native digital currency XRP for transactions, while Skrill supports a wide range of traditional and digital currencies. This difference in currency support can impact users depending on the types of transactions they need to make.

4. Regulation and Compliance: Skrill is regulated in multiple jurisdictions, adhering to strict guidelines and compliance measures to ensure the security and safety of user funds. Ripple, being a decentralized digital currency, operates with a different regulatory framework, which can affect how users interact with the platform and their level of protection.

In Summary, Ripple offers faster transaction speed, lower transaction fees, and primarily focuses on XRP currency, while Skrill supports a wide range of currencies, is heavily regulated, and ensures compliance for user security.