1. Execution Environment: Azk focuses on running multiple services in isolated, reproducible environments, similar to Docker Compose. On the other hand, Vagrant provides full virtual machines, offering more control over the environment.

2. Supported Platforms: Azk is primarily targeted towards Linux and Mac OS, whereas Vagrant supports various operating systems such as Windows, Linux, and Mac OS.

3. Configuration Management: Vagrant emphasizes using provisioners like Chef, Puppet, or shell scripts to manage configurations, while Azk relies on files like Azkfile.js for defining the project setup.

4. Networking: Vagrant allows more flexibility in networking configurations between the host and guest machines compared to Azk, which focuses more on simplifying the setup for local development environments.

5. User Base: Vagrant has a larger user base and comprehensive community support due to its longer presence in the market, while Azk caters more to developers looking for a modern, lightweight alternative.

6. Ecosystem Integration: Vagrant integrates seamlessly with various virtualization providers like VirtualBox and VMware, offering diverse options for creating and managing virtual machines, while Azk's focus is more on simplifying the workflow for developers using containerized applications.

In Summary, Azk and Vagrant differ in execution environments, supported platforms, configuration management, networking options, user base, and ecosystem integrations.