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We switched to Traefik so we can use the REST API to dynamically configure subdomains and have the ability to redirect between multiple servers.

We still use nginx with a docker-compose to expose the traffic from our APIs and TCP microservices, but for managing routing to the internet Traefik does a much better job

The biggest win for naologic was the ability to set dynamic configurations without having to restart the server

We implemented our first large scale EPR application from naologic.com using CouchDB .

Very fast, replication works great, doesn't consume much RAM, queries are blazing fast but we found a problem: the queries were very hard to write, it took a long time to figure out the API, we had to go and write our own @nodejs library to make it work properly.

It lost most of its support. Since then, we migrated to Couchbase and the learning curve was steep but all worth it. Memcached indexing out of the box, full text search works great.

If you want to use Pouchdb might as well use RxDB which is an observables wrapper for Pouch but much more comfortable to use. Realm is awesome but Pouchdb and RxDB give you more control. You can use Couchbase (recommended) or CouchDB to enable 2-way sync

If you are just starting out, might as well learn Kubernetes There's a lot of tools that come with Kube that make it easier to use and most importantly: you become cloud-agnostic. We use Ansible because it's a lot simpler than Chef or Puppet and if you use Docker Compose for your deployments you can re-use them with Kubernetes later when you migrate