1. Integration with design systems: One key difference between ProtoPie and Sympli is that ProtoPie offers seamless integration with design systems, allowing designers to easily import assets and components from popular design tools like Sketch, Figma, and Adobe XD. On the other hand, Sympli focuses more on collaboration and version control for design teams, offering features such as project management, feedback loops, and developer handoff tools.

2. Prototyping capabilities: ProtoPie is known for its advanced prototyping capabilities, allowing users to create high-fidelity interactive prototypes with complex interactions and animations without the need for coding. Sympli, on the other hand, is more focused on providing a platform for collaboration between designers and developers, offering features such as code snippets, design specs, and automated workflows to streamline the design handoff process.

3. Real-time collaboration: ProtoPie offers real-time collaboration features that allow multiple users to work on the same project simultaneously, making it ideal for remote teams or designers working in different locations. In contrast, Sympli also offers collaboration tools, but the emphasis is more on streamlining the design-to-development handoff process and ensuring design consistency across different platforms and devices.

4. Platform support: ProtoPie supports a wide range of platforms and devices, allowing designers to create prototypes for various operating systems and screen sizes. On the other hand, Sympli focuses on providing a seamless experience for web and mobile app design, with features tailored specifically for these platforms to enhance the design and development workflow.

5. User interface and learning curve: ProtoPie has a user-friendly interface with a low learning curve, making it accessible to designers of all skill levels, including beginners. Sympli, on the other hand, may have a steeper learning curve due to its focus on collaboration and design handoff processes, which may require some time to master for new users.

6. Pricing and licensing model: ProtoPie and Sympli have different pricing structures, with ProtoPie offering a subscription-based model with various plans based on the user's needs and team size. In contrast, Sympli offers a team-based pricing model where users pay per seat, with additional features and collaboration tools available at different price points.

In Summary, ProtoPie and Sympli differ in terms of integration with design systems, prototyping capabilities, real-time collaboration, platform support, user interface, and pricing and licensing models.