1. Cost: One significant difference between Microsoft Project and OpenProject is the cost. While Microsoft Project is a commercial software that requires a paid license, OpenProject is an open-source software that can be downloaded and used for free. This difference in cost can impact the budget of a project and the accessibility of the software for different organizations.

2. Platform Compatibility: Another important difference between the two is the platform compatibility. Microsoft Project is specifically designed for Windows operating systems and requires the use of Microsoft Office for full functionality. On the other hand, OpenProject is a web-based software that can be accessed from various devices and operating systems, including Windows, macOS, and Linux. This platform compatibility allows for greater flexibility and accessibility when working on projects.

3. Collaboration Features: Collaborative features are also different in Microsoft Project and OpenProject. Microsoft Project focuses more on individual project management, with limited collaboration features. OpenProject, on the other hand, emphasizes collaboration and offers features such as real-time collaboration, document sharing, and commenting on tasks. These collaboration features in OpenProject make it a better choice for teams and organizations that prioritize teamwork and communication.

4. Customization Options: OpenProject provides more customization options compared to Microsoft Project. OpenProject allows users to tailor the software to meet their specific needs through customizable workflows, custom fields, and user roles. This level of customization offers more flexibility in adapting the software to different project management methodologies. Microsoft Project, however, has limited customization options, making it less adaptable to specific project requirements.

5. Integrations: Both Microsoft Project and OpenProject offer integrations with other software tools, but the range of integrations differ. Microsoft Project has strong integrations with other Microsoft Office products, such as Excel and SharePoint, making it convenient for users who already rely on Microsoft ecosystem. OpenProject, on the other hand, has a wider range of integrations, including popular tools like Git, GitHub, and Slack. These integrations make OpenProject a more versatile software that can be seamlessly integrated with different tools used in project management.

6. Community Support: The level of community support is another key difference between Microsoft Project and OpenProject. Being a commercial software, Microsoft Project has dedicated customer support and a user community, but it is not as extensive as the open-source community that supports OpenProject. OpenProject benefits from a large and active community of users and developers who contribute to its improvement, provide assistance, and share resources. This vibrant community support of OpenProject can be valuable for users seeking help, guidance, and continuous development of the software.

In Summary, Microsoft Project and OpenProject differ in terms of cost, platform compatibility, collaboration features, customization options, integrations, and community support. While Microsoft Project is a comprehensive project management software with a commercial license, OpenProject is an open-source software that offers affordability, platform flexibility, strong collaboration features, customizable options, wide integrations, and extensive community support. Ultimately, the choice between the two will depend on the specific needs, budget, and preferences of the user or organization.