1. User Interface: Workflowy provides a simple and clean user interface where users can create nested lists effortlessly, while Workfront offers a more robust interface with project management tools and features like Gantt charts and resource allocation.

2. Target Audience: Workflowy is more suitable for individuals and small teams looking for a straightforward way to manage tasks and projects, whereas Workfront caters to larger organizations with complex project management needs.

3. Integration Capabilities: Workflowy has limited integration options with other tools and platforms, making it better suited for standalone use, while Workfront offers seamless integrations with various software applications like Salesforce, Adobe Creative Cloud, and Jira.

4. Collaboration Features: Workfront provides advanced collaboration features like real-time editing, comments, task assignments, and progress tracking, which are indispensable for teams working on large projects, whereas Workflowy focuses more on individual task management and lacks extensive collaboration functionalities.

5. Customization Options: Workfront allows users to customize workflows, project templates, and reports to suit specific project requirements, offering more flexibility in project management, while Workflowy has limited customization options, primarily focusing on list organization and structure.

6. Reporting and Analytics: Workfront provides detailed reporting and analytics features to track project progress, resource utilization, and team productivity, offering insights for better decision-making, whereas Workflowy lacks in-depth reporting capabilities and analytics tools.

In Summary, Workflowy is a simple list-making tool suitable for individuals and small teams, while Workfront is a comprehensive project management platform designed for larger organizations with advanced project needs.