We started off with AWS SES, but found it to be lacking in diagnostics and reporting. Mandrill is a quantum leap forward in this regard. Has some other really neat features carried over from MailChimp (templating). Mandrill
Parked in front of an nginx instance that serves all of our static assets. Performance and reliability have been excellent, and the header pass-through rules are wonderful. Price is affordable, as well. Amazon CloudFront