1. Integration with other tools: Active Collab offers integrations with popular tools like Google Drive, Dropbox, and Slack, making collaboration seamless across different platforms. Confluence, on the other hand, integrates well with Atlassian's own suite of tools such as Jira, Bitbucket, and Trello, providing a comprehensive ecosystem for project management and documentation.
2. User Interface: Active Collab has a more user-friendly and intuitive interface, making it easier for team members to navigate and use the software effectively. Confluence has a steeper learning curve with a more complex interface, which may require additional training for new users to fully utilize all its features.
3. Cost: Active Collab follows a subscription-based pricing model, which may be more cost-effective for smaller teams or businesses with limited budgets. Confluence, being part of the Atlassian suite, offers various pricing tiers that may be more suitable for larger enterprises with extensive collaboration and documentation needs.
4. Customization: Active Collab allows for more customization options, such as creating custom templates and workflows to fit specific project requirements. Confluence, while flexible, may have limitations in terms of customization compared to Active Collab, which offers more tailored solutions for different project workflows.
5. Mobile Accessibility: Active Collab offers a user-friendly mobile app for iOS and Android devices, allowing team members to stay connected and collaborate on the go. Confluence also has a mobile app, but it may not provide as seamless an experience as Active Collab's app, making it more challenging for users to work efficiently from their mobile devices.

In Summary, Active Collab and Confluence have key differences in terms of integration with other tools, user interface, cost, customization options, and mobile accessibility, catering to different needs and preferences in project management and collaboration.