1. Deployment Model: AppDynamics offers both on-premise and SaaS-based deployment options, catering to different business needs and preferences. In contrast, ManageEngine Applications Manager is primarily offered as an on-premise solution, providing more control over data security and customization for enterprises that prefer to manage their applications in-house.

2. Scalability: AppDynamics is known for its high scalability, capable of monitoring complex and large-scale distributed applications with ease. ManageEngine Applications Manager, while still capable of handling a significant number of applications, may exhibit limitations in scalability when compared to AppDynamics, especially in environments with a vast number of interconnected systems and applications.

3. Real-time Monitoring: AppDynamics excels in real-time monitoring capabilities, providing instant insights into application performance and user experience. ManageEngine Applications Manager, while offering real-time monitoring features, may not offer the same level of detailed and actionable insights as AppDynamics, making it more suitable for basic monitoring needs.

4. Integration Capabilities: AppDynamics has a strong ecosystem of integrations with various third-party tools and platforms, allowing seamless integration with other systems for enhanced functionality and automation. ManageEngine Applications Manager, while offering integration capabilities, may have a more limited range of integrations compared to AppDynamics, potentially requiring custom development for specific integrations.

5. Cost Structure: AppDynamics is typically considered a higher-priced solution, targeted towards larger enterprises with complex application environments that require advanced monitoring capabilities. ManageEngine Applications Manager, on the other hand, offers a more cost-effective option for organizations with budget constraints or simpler monitoring requirements, providing a comprehensive monitoring solution at a lower price point.

6. Customization and Extensibility: AppDynamics provides extensive customization options and a robust extensibility framework, allowing organizations to tailor the monitoring solution to their specific needs and integrate custom functionality seamlessly. In comparison, ManageEngine Applications Manager may have limitations in terms of customization and extensibility, potentially requiring more manual effort for implementing advanced monitoring features tailored to unique business requirements.

In Summary, the key differences between AppDynamics and ManageEngine Applications Manager lie in their deployment models, scalability, real-time monitoring capabilities, integration capabilities, cost structures, and customization and extensibility options.