1. Scalability: Datadog is designed to scale easily with a large number of hosts, making it suitable for enterprises with complex infrastructures. Prometheus is more suitable for smaller setups as it requires manual sharding for scaling. Zabbix, on the other hand, is known for its ability to handle a large number of monitored devices efficiently.

2. Data Storage: Datadog offers a cloud-based solution for data storage, making it easy to scale and access data from anywhere. Prometheus stores data locally, which can be a limitation for large-scale setups that require centralized data access. Zabbix allows users to choose between local and cloud storage options, providing flexibility based on specific requirements.

3. Alerting Capabilities: Datadog provides robust alerting features with customizable thresholds and notification mechanisms. Prometheus has basic alerting capabilities that require additional configurations for advanced setups. Zabbix offers extensive alerting functionality with support for escalations, multiple notification methods, and acknowledgment mechanisms.

4. Monitoring Capabilities: Datadog offers a wide range of integrations and plugins for monitoring various technologies and services, making it a versatile solution. Prometheus focuses on monitoring cloud-native environments and is highly suited for Kubernetes ecosystem monitoring. Zabbix, on the other hand, is known for its comprehensive monitoring capabilities for IT infrastructure components.

5. Ease of Use: Datadog is known for its user-friendly interface and easy setup process, making it ideal for organizations looking for a quick deployment. Prometheus requires more configuration and expertise to set up, making it better suited for technically skilled teams. Zabbix provides a balance between ease of use and advanced monitoring capabilities, catering to both beginners and experienced users.

6. Community Support: Datadog has a strong community support system with extensive documentation and resources available for users. Prometheus has an active open-source community backing it up, providing continuous updates and new features. Zabbix boasts a dedicated community forum and extensive knowledge base, offering support and guidance for users at all levels of expertise.

In Summary, Datadog, Prometheus, and Zabbix each offer unique strengths and cater to different monitoring needs based on factors such as scalability, data storage, alerting capabilities, monitoring focus, user-friendliness, and community support.